An antidepressant drug suppresses the herpes simplex virus. Tranylcypromine, sold since the 1960s as Parnate, reduces flare-up in previously infected animals with the herpes virus. Tranylcypromine blocks the activity of the LSD1, a protein found in humans and other mammals. "The herpesvirus uses LSD1 to activate some of its own genes to infect a host and later to awaken from its dormant state in the host’s sensory nerve cells." This activation is what unleashes the virus and cause the symptoms.
![](http://nonprofitstdtesting.org/wp-content/gallery/herpes-oral/recurrent-herpes.jpg)
By blocking the viral gene activation, tranylcypromine makes the epigenetic change in the virus, but an alternation in its gene activity that does not change the underlying DNA structure. They tested this on mice, rabbits and guinea pigs.
![](http://2xmetropolitan.com/wp-content/uploads/2014/07/female-genital-herpes-pictures-virus.jpg)
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